High-dose vitamin D3 (60,000 IU weekly) correlates with ankle swelling via hypercalcemia-induced fluid retention and kidney dysfunction, though rare at prescribed doses under monitoring.
Mechanism
Excess D3 boosts calcium absorption > blood levels (hypercalcemia), impairing kidneys' sodium/water excretion, causing peripheral edema.
Risk Factors
Single >300,000 IU or chronic overdose risks it; symptoms with calcium >12.9 mg/dL include nausea, weakness.
Management
Stop supplement, hydrate, check labs; safe weekly for deficiency if doctor-guided.
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