Curcumin, the primary bioactive compound in turmeric, reduces inflammation by inhibiting NF-κB and other pathways while boosting mood through BDNF and serotonin modulation.
Anti-Inflammatory Action
Curcumin blocks pro-inflammatory cytokines like TNF-α, IL-6, and CRP, as shown in RCTs where 500-2000mg daily lowered markers by 20-60% in arthritis and metabolic conditions. Pairs well with black pepper (piperine) for 2000% better absorption.
Mood Benefits
By crossing the blood-brain barrier, curcumin elevates brain-derived neurotrophic factor (BDNF), combating depression symptoms comparably to fluoxetine in trials; reduces oxidative stress linked to anxiety.
Practical Use
Dose 500mg curcumin (95% extract) 1-2x daily with fat/piperine; golden milk or your supplement stacks enhance bioavailability without blood sugar impact. Effects build over 4-8 weeks.
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